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Patients undergoing cancer treatment, as glutathione may interfere with the effectiveness of some chemotherapy drugs by protecting cancer cells from oxidative damage

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A 'substrate-limitation' model in FM is supported by elevated homocysteine levels observed in FM/chronic fatigue syndrome cohorts, by associations between symptoms and the MTHFR C677T (rs1801133) variant, and by gene-environment interactions showing that rs1801133 modifies the effect of physical activity on fatigue

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