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But due to the difficulties on obtaining and immobilization of suitable ligand, this chromatography technique is not used as widely as other ones

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reported that after DSS removal for an additional 5 days, mice exhibited reduced colitis scores and mild body weight loss, whereas mice treated with the NK-1R antagonist during the recovery phase showed increased colitis clinical scores and further decreased body weight, indicating the therapeutic effects of SP in the recovery phase of colitis [54]

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The main allosteric inhibitors are GTP and ATP

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Furthermore, animal studies have shown that AKG-derived metabolites can be detected in the cerebrospinal fluid, providing indirect evidence that AKG or its metabolic products are capable of crossing the blood-brain barrier [15]

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