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448 Moreover, energy demand changes dramatically when immune cells shift from a resting state to an active state, which often causes energy deficits when cells become senescent and, consequently, contributes to the metabolic remodeling accompanied by the altered secretion of cytokines, chemokines, and inflammatory mediators

Tobacco carcinogens cause direct DNA damage, including adduct formation, and amplify the mutagenic effect of other hepatotoxins such as aflatoxin B1 [32, 33]

Hippocampal hyperactivity, therefore, increases excitatory input to the PFC and this increased tonic activity can lead to reductions in synaptic density [117]
