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Moreover, the safety profiles of both medications have been extensively studied, revealing that while they may cause gastrointestinal side effects, these are often mild and transient
Proper conformation restriction can be used to control the ligand conformation and make the molecule biased to the desired conformation binding with the target proteins as too many free rotation bonds of drug molecules are not conducive for binding [29, 30]
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The International Society of Sports Nutrition (ISSN) concluded that creatine is the most effective nutritional supplement available for athletes interested in increasing high-intensity exercise capacity and lean body mass [12]
