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Elucidation of this substrate-turnover-dependent regulation of CDO activity began with the discovery of this rare intramolecular cross-link between active-site residues Cys93 and Tyr157 in the X-ray crystal structure of CDO (Simmons et al

Do not exceed the recommended daily intake

Furthermore, a similar trend applies to acid solvation: p K a increases roughly linearly with stronger solvation of the conjugate base product (e.g., A ) and easier desolvation of the acid reactant (e.g., HA

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