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Antiobesity drugs act via any of four mechanisms: 1) decreasing energy intake, 2) increasing energy expenditure or modulating lipid metabolism, 3) modulating fat stores or adipocyte differentiation, and 4) mimicking caloric restriction

The REDEFINE 4 trial: the definitive showdown Everything discussed above relies on cross-trial comparisons, which carry inherent limitations

Vessel-associated transforming growth factor-Beta1 (TGF-beta1) is increased in the bronchial reticular basement membrane in COPD and normal smokers

PCOS is diagnosed using the Rotterdam Criteria-2003, which includes two of the following features: oligo/amenorrhea, anovulation, infertility