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free-drug occupancy method (albumin Kd 1.86 uM, free fraction 0.29%): Willard JCI Insight 2020
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But for women with a BMI over 30, weight-related comorbidities (hypertension, type 2 diabetes, sleep apnea), or psychological impacts of significant weight gain, the clinical need may be substantial
without enough B12, cell division and growth are limited
