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In 2005, a controlled trial (N = 22 LOE3b) of LC (50 mg/kg daily for 6 months) in children with RS showed a significant increase in heart rate variability, suggesting that LC supplementation may reduce the risk of sudden death in children with RS [86]

This can lead to loss of biological activity, significantly limiting its use in nutraceutical applications. Microencapsulation, in contrast, provides a stable, comprehensive solution to astaxanthins chemical instability and sensitivity to oxidation. Gomez added the encapsulation of spirulina further enhances the antioxidant properties of astaxanthin, amplifying the benefits of both compounds