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Description
DCA and CDCA can act as metabolic danger signals and activate both signals 1 and 2 of the NLRP3 inflammasome, which increases IL-1 release, whereas LCA can suppress NLRP3 via TGR5 signaling and can reduce macrophage uptake of oxidized LDL [30]
[DOI] [PMC free article] [PubMed] [Google Scholar] 75.Gong J.M., Lee D.A., Schroeder J.I
Author contributions Y-SK, I-SK, AT, JG, and H-SY designed the experiments
Comput Struct Biotechnol J (2021) 19:15360
