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Pearsons correlation with two-tailed p -values was used to assess the relationship between gene fitness values in AVI/CAZ and the single conditions in the combination

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The flow was measured in the M1 segments of both left and right middle cerebral arteries (MCAs) using a parasagittal two-dimensional single-slice phase contrast (PC) sequence with peripheral pulse gating and the following parameters: TR/TE = 89.22/9.03 ms, flip angle = 15 degrees, slice thickness = 4 mm, FOV = 140 140 mm 2 , matrix size = 256 256 interpolated to 512 512, receiver bandwidth = 130 Hz/pixel, averages = 3, number of phases = 25, and velocity encoding (VENC) = 100 cm/s in through-plane direction