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First of all, the dual role of the gastrointestinal system - dedicated not only to nutrient absorption from the lumen, but also to their supply to other tissues via the blood - may present one of the reasons for the intestine-specific susceptibility to TD

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The persistent hyperglycemia in diabetic patients leads to the massive deposition of AGEs in endothelial cells, glomerular basement membrane and podocytes, directly damaging the normal structure of the glomerulus, impairing filtration function, and leading to the production of proteinuria (Wu et al., 2021)

Untargeted metabolomics identifies glutamine metabolism as a driver of chemoresistance in acute myeloid Leukemia