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Studies have demonstrated that SASP factors recruit immune cells to the site of tissue damage, stimulating the removal of damaged and aging cells [13, 36]

Many growth factors such as transforming growth factor (TGF)-, 2 platelet-derived growth factor (PDGF), 3 epidermal growth factor (EGF), 4 and fibroblast growth factor (FGF), 5 as well as interleukin (IL)-1 6 and tumor necrosis factor (TNF), 7 have been evaluated in a wide spectrum of in vivo and in vitro experiments to observe their effects on different elements included in the healing process

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For IVDs injected with DFbs, the IVD height improved when the disc was under pressure, with biomechanical effects of bearing pressure and pressure curves similar to those observed for sham IVDs (Fig