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Increased ROS levels in cancer cells have the capacity to suppress the activity of mitogen-activated protein kinase (MAPK), protein tyrosine phosphatases (PTPs), phosphatases, and tensin homolog (PTEN), which in turn may promote both cell proliferation and survival (Moloney And Cotter 2018)

PLA intensity was also reduced in the polyploid U11 clones despite comparison with a diploid control (Fig

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