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Description
Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases

Ferris HA, Perry RJ, Moreira GV, Shulman GI, Horton JD, Kahn CR

PMID: 2007906

This lack of homeostasis affects acidification of vesicles transported to the lysosomal compartment for degradation [114]
