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Description
Hypoxia reduces ER-to-Golgi protein trafficking and increases cell death by inhibiting the adaptive unfolded protein response in mouse beta cells
The increased 1,3BPG levels activate the 2,3BPG shunt, producing 2,3BPG needed to regulate oxygen binding to hemoglobin
Muscle has small amounts of some of the Pentose Phosphate Pathway enzymes, because it has little need for synthetic reactions, and therefore, little need for NADPH
Therefore, targeting tight junction integrity can be the therapeutic approach for the treatment of related diseases in the gastrointestinal tract
