glutathione synthetase deficiency omim Frontiers | Case report: A
Description
Nuclear PKM2 is also a transcriptional co-activator of the hypoxia-induced factor-1 (HIF-1) complex
doi: 10.1016/B978-0-12-801284-0.00004-X
This creates a positive feedback loop where COX-2 activity is further boosted increasing the production of pro-inflammatory prostaglandins, which exacerbate oxidative stress and tissue damage (Simmons et al., 2004
732 Reduced antioxidant capacity is another important feature of ferroptosis
