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In AD, the brain shows hallmark features of amyloid beta (A) plaque accumulation and neurofibrillary tangles formed by hyperphosphorylated tau protein [2], although prior to diagnosis, a series of neuropathological changes and cognitive decline occur [3]

Evaluation included height, weight, waist circumference (WC), grip strength (HG) by dynamometry, the Short Physical Performance Battery Test (sppb), body composition and BMD in femoral neck (by Lunar)