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Human monocytes/macrophages release TNF alpha in response to oxidized LDL

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SLC22A5 mutations impair OCTN2 function, causing primary carnitine deficiency (PCD) (1517), an autosomal recessive disorder characterized by skeletal myopathy, progressive cardiomyopathy, hypoglycemia, and hyperammonemia

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9 AT targeted against the mitochondria The mitochondria are significant producers of reactive species, and mitochondrial damage is one of the major contributors to the onset of various diseases and aging

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Blood samples were collected over a short 4h duration, which is a limitation as the time course was truncated before plasma ascorbate had returned to baseline, thus limiting the AUC findings

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