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Indeed, in silico studies could show that disc degeneration shifts the instantaneous center of rotation in the cervical spine 34 and leads to increased loading of the cervical facets joints 35

The results from the tail suspension test, as depicted in Figure 4, provide compelling evidence on the effects of different treatments on depressive-like behaviors in an animal model

These experimental systems often measure endpoints such as cellular migration capacity, collagen fiber organization, and biomechanical properties of healing connective tissue

Serious adverse events are rare, and the drug was well-tolerated even at the highest studied doses