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The elevated adipokine levels of TNF- and NF-B were not obliterated in the group fed a ketogenic diet
This hypothesis is supported by several studies that have shown supplementation with SAM improves depressive symptoms (104-107)

doi: 10.1126/science.1231677

Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial
