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The potent de-lactylation activity of HDAC1-3, observed in both cellular and in vitro purified proteins, was first identified by Yruela et al., particularly regarding Kd-la [53]

S., et al., Evaluation of Plasma Levels of NFL, GFAP, UCHL1 and Tau as Parkinson's Disease Biomarkers Using Multiplexed Single Molecule Counting, Scientific Reports 13, no

Accurate assessment of the scope of this phenomenon remains challenging due to its predominantly clandestine nature, frequent polypharmacy, and the widespread availability of unregulated substances of uncertain composition and purity