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Also, Matrigel constructs of human chondrocytes from the knee joint and TMJ implanted in nude mice showed enhanced anabolic responses after LOXL2 transduction, including increased expression of sex determining region Y-box containing gene 9 (SOX9), aggrecan (ACAN), and COL2A1, whilst reduced the levels of extracellular matrix (ECM)-degrading enzymes matrix metalloproteinases and inhibited chondrocyte apoptosis ( The components of extracellular matrix are vital for the maintenance of phenotype and function of chondrocytes (Shi et al., 2017

J Am Vet Med Assoc

A comprehensive review of the vascular consequences of diabetes in the lower extremities: current approaches to management and evaluation of clinical outcomes