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Unresolved inflammation results in formation of vulnerable plaques characterized by enhanced macrophage apoptosis and defective efferocytosis of apoptotic cells resulting in necrotic cell death leading to increased smooth muscle cell death, decreased extracellular matrix production, and collagen degradation by macrophage proteases

167,168 In addition, the colonization of symbiotic colonies during the neonatal period in mice reduces CpG methylation in the gene encoding CXCL16, thus protecting mice from the enhanced mucosal accumulation of invariant natural killer T (iNKT) cells in the lung