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Indeed, in one hand, their activation is involved in neuroinflammation which endanger neurons via cytokines overproduction and on the other hand, atrophy and loss of activity leads to reduced neuronal protection ( 2+ oscillations than young ones under purinergic stimulation

Curr Pharm design (2018) 24(34):407789
The effect of alpha-lipoic acid on temporary threshold shift in humans: A preliminary study

These findings suggest a potential involvement of ferroptosis in the pathogenesis of EAE and SPMS [195]