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Horyn, and Ilana Nissim (Metabolomics Core Facility, Childrens Hospital of Philadelphia) for performing the isotopomer enrichment analysis and metabolite measurements, Eric Blankemeyer (Small Animal Imaging Facility, University of Pennsylvania) for assistance with CT imaging, and the Molecular Pathology and Imaging Core (University of Pennsylvania) for histology services

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Emodin in combination with berberine significantly inhibits salt-inducible kinase 3 (SIK3) activity, reducing cell growth and inducing cell cycle arrest and apoptosis in breast cancer cells