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Interestingly, both p53 and FOXO control a distinct set of genes that are not targets of Nrf2 activity, even though all three factors induce HMOX1 expression and, therefore, Fe(II) storage and secretion, that plays a role in breast tumorigenesis, highlighting the role of antioxidants in cancer promotion 28

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doi: 10.1016/j.conb.2023.102798 42