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In some people, coffee can cause looser stools or even diarrhoea, but it rarely causes constipation, and may even help prevent it

Importantly, histopathological sections indicated no obvious adverse effects

Its mechanism of action involves various pathways, such as the modulation of gut microbiota and metabolic profiles [254], the activation of autophagy via the AMPK/SIRT1 pathway [255], and the regulation of macrophage activation and their phenotypic changes [256]

In any case, the most commonly shared hallmark of different forms of cholestasis is an interruption of the enterohepatic circulation of bile acids and consequent retention of toxic bile salts in the bloodstream and at the intracellular level, leading to fibrosis and cirrhosis [173]