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Overall, GPX4 inhibitors could have a combined effect on eliminating senescent cells in the tumour and tumour microenvironment and the subset of highly plastic, mesenchymal-like cells that promote therapy resistance

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Further investigations are needed to elucidate the mechanism of action of most polyphenols studied, and an essential study of dose assessment is highly required to standardize the application of natural polyphenols in UTI treatment

Nevertheless, three of these compounds impair parasite development, although through a mechanism unrelated to eryptosis and yet to be elucidated