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This nexus between NK cells and macrophage and monocyte populations intensifies the production of inflammatory factors, thereby exacerbating the inflammatory response (114)

Their benefits are mediated through diverse mechanisms, including modulation of the gut microbiota, competitive exclusion of pathogens, regulation of immune and inflammatory pathways, and interactions with host metabolism and the gutbrain axis

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Furthermore, metformin was shown to mitigate the effects of testosterone-induced hormone receptor expression, and restore testosterone and HOXA10 expression levels (Ohara et al., 2021)