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Gene therapy in patients with transfusion- dependent beta-thalassemia

The first trial was an investigator-initiated, randomized controlled study designed to evaluate the safety and efficacy of single-dose DPSC therapy, conducted at Beijing Stomatological Hospital from May 22, 2020, to February 16, 2023 (Ethical code: CMUSH-IRB-KJ-PJ-2019-14)

This was investigated further, and, when faced with a low-glucose/low-glutamine environment, these cells were shown to rely on fatty acid oxidation or acetate for energy to mount a cytokine response, further highlighting the metabolic resilience of NK cells
