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When an antigen is introduced into the body, B cells generate antibodies to neutralize pathogens, whereas T cells identify and destroy infected or abnormal host cells, thereby reducing infection spread and maintaining immune homeostasis [9]

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Bromelain acted by removing the extracellular domains of the CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and thus enhancing T cell activation through CD2