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doi: 10.1186/s41479-018-0048-3 240 WangZLiHLiJYangCGuoXHuZet al
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Smoking reduces nitric oxide (NO), which attenuates endothelial cell-dependent vasodilation and promotes intimal cell hyperplasia, leading to endothelial dysfunction and chronic kidney disease (21)

Conversely, tumors with KRAS activation or PHGDH amplification or overexpression show enhanced de novo serine synthesis, reducing their sensitivity to dietary restriction [25, 30]
