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The polysaccharides in okra activate the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) pathway, improve insulin signaling through insulin receptors, and eventually regulate the extracellular signal-regulated kinase (ERK)/ c-Jun N-terminal kinase (JNK)/mitogen-activated protein kinase (MAPK) pathway

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This recognition can enhance phagocytic capacity or activate the secretion of pro-inflammatory cytokines ( 2.3 Mechanisms of macrophage-mediated myocardial injury Activated macrophages exacerbate SRMI through multiple, highly synergistic molecular mechanisms that extend far beyond simple cytokine release