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Both systems complement the GSH system in determining protein thiol/disulfide status, a primary factor in redox signaling

The inflammation in pulmonary fibrosis is characterized by the activation of fibroblasts through several pathways, like the TGF-/Smad pathway, epithelialmesenchymal transition, and oxidative stress, which causes tissue stiffening and scarring

Thus, NAC may be a valuable reagent for the intervention of tendon injury

In general, many clinical and experimental studies have shown more beneficial results when glutamine was administered as an intravenous solution, when compared to enteral routes