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NTDs include various malformations, such as lesions of the brain (e.g., anencephaly, encephalocele) or lesions of the spine (spina bifida), which are devastating and usually incompatible with life (57)

Kolker S, Koeller DM, Okun JG, Hoffmann GF: Pathomechanisms of neurodegeneration in glutaryl-CoA dehydrogenase deficiency

Fattal O, Budur K, Vaughan AJ, Franco K

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