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Similar content being viewed by others Introduction Propionic acidemia (PA) is an inborn error metabolic disorder caused by mutations in the gene responsible for encoding propionyl-CoA carboxylase (PCC)

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This NAD + deficit directly impairs sirtuin activity (SIRT), compromising their regulation of mitochondrial biogenesis via PGC-1, antioxidant defense through FOXO transcription factors, and metabolic adaptation via HIF-1 modulation [106, 107]

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