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A reliable biomarker of PA is elevated propionate levels in both blood and urine, as observed in PA patients and mouse models, although propionate is often underreported due to the need for advanced analytical techniques ( Our recent work demonstrated that ACSS3 activity in the liver is attenuated in Pcca / (A138T) mice ( If propionyl-CoA hydrolysis were highly efficient, the accumulation of propionyl-CoA might not take place the primary issue, and the elevated propionate or other metabolites could instead be the main disease-causing factor

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Can Combined Blood Neutrophil to Lymphocyte Ratio and C-Reactive Protein Be Used for Diagnosis of Spontaneous Bacterial Peritonitis