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thus, the complete picture of how full-length HGF recruits and dimerizes c-MET has not been depicted, hindering our understanding of the exact activation mechanism of c-MET

The adenosine binding pocket is strikingly similar, with the ribose moiety stacking with the conserved Trp61 residue and forming a network of polar interactions linking across the dimer interface via the conserved Glu71-His72 motif (Figs

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