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52,54-56 A three-month study of a supplement containing a mixture of curcuminoids (at 0.43 mg per 1,000 kilocalories in the diet) plus hydrolyzed collagen and green tea extract in 42 adult dogs with osteoarthritis found the supplement did not improve lameness or owners subjective assessment of mobility, but significantly reduced veterinarians subjective assessment of pain upon movement of affected limbs

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Glycine and B12 may help reduce fatigue and enhance tolerability

We propose that the underlying mechanism behind that impact may be related to the mitigation of cellular oxidative damage and glycolipotoxicity, according to previous evidence from preclinical and clinical studies