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Reviewed by Esther A Torres MD, AGAF Professor of medicine, University of Puerto Rico School of Medicine, San Juan Esther A Torres MD, AGAF Professor of medicine, University of Puerto Rico School of Medicine, San Juan

During the early titration phase when GI symptoms may limit exercise tolerance, walking is often the only practical option
This suggests that combined treatment with EGFR and c-MET inhibitors could be necessary in a subset of patients to circumvent the onset of resistance to these drugs