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Chait A, Brazg RL, Tribble DL, Krauss RM

Leveraging paired single-nucleus and spatial transcriptomic datasets, we annotate 75% of identified cell clusters, revealing striking molecular diversity in cell types and states across development

Replacement therapy with the drug in regimens of up to 4g daily reverses such clinical symptoms as severe muscular weakness, hypoglycaemia and intellectual retardation seen in patients more severely afflicted with SCD, and can be life-saving in some instances

KET is the prototypical non-competitive antagonist at N -methyl-D-aspartate glutamate receptors and a clinically approved anesthetic