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Description
Recent efforts have focused on the use of drugs already approved by the Food and Drug Administration (FDA) for other diseases that have also shown efficacy in delaying cystogenesis, including pioglitazone, sirolimus, and metformin (Table 1) [912]
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IGF-1 displays more binding sites for SHP2 (a phosphatase related to growth) and seems more prone to recruit Cbl [121] (an E3 ligase that targets the receptor for ubiquitination and destruction) and thus may explain a different regulatory mechanism not mediated by serine phosphorylation, and thus not so sensitive to metabolic derangements
It is critical to understand what BPC-157 is NOT: It is not an FDA-approved drug
