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It is important to note that nutritional ketosis typically occurs in the context of low insulin levels, which lead to increased circulating free fatty acids (FFAs), enhanced mitochondrial uptake of FFAs, and elevated ketone body production

[DOI] [PMC free article] [PubMed] [Google Scholar] 440.Sen B, Guilluy C, Xie Z, Case N, Styner M, Thomas J, Oguz I, Rubin C, Burridge K, Rubin J

A dual-delivery strategy is emerging, such as combining succinate with SDH inhibitors or pairing itaconate with lactate transport activators to simultaneously dampen inflammasome activation and restore mitochondrial metabolism [224]

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