glutathione vs glutamine cancer Targeting metabolism as a therapeutic strategy for Glutamine metabolism in cancer. Cancer

After phenylketonuria, glycine encephalopathy is the most frequently occurred inborn error of amino acid metabolism [33]

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If glutathione constitutes a glutamate reservoir, then inhibiting GGT with acivicin should lead to decreased cellular glutamate, as this enzyme is upstream of the ultimate liberation of glutamate from the cycle (Fig