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Furthermore, protease-activated receptor 2 (PAR2) signaling in melanocytes amplifies oxidative and inflammatory responses through the Akt/NF-B axis, elevating cytokine production and reducing antioxidant defenses, based on CAT and SOD activity, exacerbating skin inflammation 126

Patients with FR-positive platinum-resistant advanced-stage epithelial ovarian, primary peritoneal, or fallopian tube cancers were randomized to receive chemotherapy (paclitaxel, PLD, or topotecan) or mirvetuximab soravtansine

Particularly, using Asiatic acid in interstitial cystitis has proven to be successful in rats model of cystitis induced by cyclophosphamide, this resulted in the decrease of bladder pressure, detrusor overactivity the normalization of biomarker levels and reduction of bladder edema and thickness of urothelium

Secondly, carnosine can inhibit the glycation reaction of the lens and reduce the formation of AGEs (119)