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Metabolic reprogramming is regarded as a hallmark of cancers because of the high energy/anabolism needs for cancer cell growth 16

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G6PD deficiency shifts polarization of monocytes/macrophages towards a proinflammatory and profibrotic phenotype

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In cases where the organism produces large amounts of uric acid due to increased purine catabolism, uric acid can lead to the formation of urate crystals in the kidneys

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