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Risks such as infection, allergic reactions, or improper administration must be considered

This is corroborated by the fact that lipid-ROS first localised to the mitochondrial distribution in ferroptosis triggered by cystine deprivation and erastin [70]

One notable point is that as a late-phase cytokine, the increase of HMGB1 release is tightly associated with increased mortality in animal models of sepsis (23, 3537)

The first studies focused on LXA4 levels and LXA4 to PMN ratio measured in BAL fluids of CF subjects compared to non-CF subjects and suggested a relative decrease of LXA4 to PMN concentrations (Karp et al., 2004)