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Malinow's concern was based on the result of our study of the Framingham Offspring cohort (38), which showed that, in subjects who were taking vitamin supplements, folic acid fortification was associated with significantly higher serum total homocysteine (tHcy) concentrations than at baseline ( Figure 2 )
However, juvenile or adult onset manifestations characterized mainly by ataxia, dementia, and psychosis have been described [2, 4]
Antioxidant substances have been classified into two main systems, the enzymatic system and the non-enzymatic system
