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138 , 139 Upon activation, PI3K/Akt signaling confers resistance to chemotherapy through its antiapoptotic effects as mediated by phosphorylation of several downstream targets

Hence in this study, we used objective-independent techniques such as FVA, FSA and metabolite centric analysis along with a basal level of biomass as a constraint, thus ensuring the maintenance to biological activities

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Zhang K, Zhu J, Wang R, Gong L,Feng F, Liu WHL, Qu W
