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It depends on two primary variables: Volume of distribution (Vd) Clearance (CL) Formula: t = (0.693 Vd) / CL Vd = how widely the drug is distributed CL = how quickly it's eliminated Interpreting the Curve KOTC Tip: It takes ~45 half-lives to reach steady state or complete elimination

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Due to the lack of antimicrobials, sterile water can easily be contaminated once exposed to surroundings and even yourself

This involves regular, liberal use of moisturizers and intermittent (e.g., twice-weekly) application of topical treatments to previously affected areas to stop new flares from starting [20]